One way to find out how long a drug will last in your body is to measure its half-life. The half-life is the time it takes for half of the drug to be eliminated from the body. How Long do Opiates Stay in Your System? October 15, 2018 - Detox & Withdrawal, Opioid Addiction - 8 Comments. Do you need to pass a drug test? Select an option below to learn the specific opioid detection window. I'm so sorry for your ongoing pain. Pain meds. used to come out of my system quite quickly because they are instant acting. When I was taking Norco and other meds., I could take one in the afternoon, and when tested the following day, I didn't test positive. How Long Does Tramadol Stay in your System. Generally tramadol will stay in your system for 1-2 days but this varies depending on your body and how it is tested. Percocet contains oxycodone and acetaminophen, both of which have risks for dangerous interactions and overdoses as long as they're in your system. Learn more about methamphetamine and how long can meth be detected in your body's system through urine, blood, saliva, and hair tests. How long tramadol will stay in the body has to do with the medication’s elimination half-life, which is the average amount of time it takes for half of the drug to be cleared from the body. It’s also important to note that heroin can generally be detected much longer in the systems of long-term, heavy users. This is because excessive use causes the drug to be stored in fatty tissues that take much longer to be flushed out than substances that are merely in the blood and other bodily fluids.Heroin is considered to be one of the. Depending on use, dose, sensitivity of the test, and metabolic rate of the person, between 3 and 8 days. To prevent an overdose of either medication it can be helpful to understand how long they stay in the body so that you don't risk overlapping a new dose of either ingredient with medication that's still circulating in your system.